Comparison · Comparison
OpenAI vs Azure OpenAI vs Anthropic: choose by constraints, not by hype.
Model leaderboards change monthly; your constraints don’t. Where your data may go, which cloud you already pay for, how procurement works and what your use case needs decide more than a benchmark. Here’s how we choose — and why we keep the choice reversible.
By Nythrex EngineeringUpdated 2 min read
Your application
- Features
- Prompts
- Tools
- Evals
Model gateway (yours)
- Routing per task
- Fallbacks
- Budgets
- Logging
- Provider keys
Platforms
- OpenAI API
- Azure OpenAI
- Anthropic API
- AWS Bedrock
- Google Vertex AI
- Self-hosted open-weight
How the options differ
| Direct API (OpenAI / Anthropic) | Via your cloud (Azure OpenAI, Bedrock, Vertex AI) | Self-hosted open-weight | |
|---|---|---|---|
| Access to newest models | Usually first | Often soon after; varies by model and region | Depends on open releases |
| Contract & billing | Separate vendor contract | Inside your existing cloud agreement | Your infrastructure costs |
| Networking & identity | Public API with keys | Private networking and cloud identity options | Fully under your control |
| Data residency | Regional options exist for eligible customers — check terms | Regional deployments in your cloud | Wherever you run it |
| Operations effort | Lowest | Low | Highest: GPUs, scaling, updates |
| Best for | Fast start, newest capabilities | Enterprises with cloud commitments and security reviews | Strict data control, offline, high steady volume |
Decision guide
- 1
Start with hard constraints
Data may not leave the EU? Must stay in your tenant? Offline? These eliminate options before quality comparisons begin.
- 2
Follow your cloud
Already on Azure with Microsoft procurement: Azure OpenAI is usually the smoothest path. On AWS: Bedrock gives you Claude and other models under your AWS account. On GCP: Vertex AI offers Gemini and Claude.
- 3
Measure quality per task
Run your eval set against two or three candidate models. Differences on your task and language often don’t match public benchmarks.
- 4
Model the cost at real volume
Include caching, routing and output length. See the LLM cost calculator.
- 5
Keep an exit
Abstract the provider behind your own gateway and keep prompts and evals in your repository.
Frequently asked questions
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