Nythrex

Comparison · Comparison

OpenAI vs Azure OpenAI vs Anthropic: choose by constraints, not by hype.

Model leaderboards change monthly; your constraints don’t. Where your data may go, which cloud you already pay for, how procurement works and what your use case needs decide more than a benchmark. Here’s how we choose — and why we keep the choice reversible.

By Nythrex EngineeringUpdated 2 min read

Your application

  • Features
  • Prompts
  • Tools
  • Evals

Model gateway (yours)

  • Routing per task
  • Fallbacks
  • Budgets
  • Logging
  • Provider keys

Platforms

  • OpenAI API
  • Azure OpenAI
  • Anthropic API
  • AWS Bedrock
  • Google Vertex AI
  • Self-hosted open-weight
Keep a thin gateway between your app and providers. The platform choice then stops being a one-way door.

How the options differ

General patterns — features, regions and terms change frequently. Verify current provider documentation for your case.
Direct API (OpenAI / Anthropic)Via your cloud (Azure OpenAI, Bedrock, Vertex AI)Self-hosted open-weight
Access to newest modelsUsually firstOften soon after; varies by model and regionDepends on open releases
Contract & billingSeparate vendor contractInside your existing cloud agreementYour infrastructure costs
Networking & identityPublic API with keysPrivate networking and cloud identity optionsFully under your control
Data residencyRegional options exist for eligible customers — check termsRegional deployments in your cloudWherever you run it
Operations effortLowestLowHighest: GPUs, scaling, updates
Best forFast start, newest capabilitiesEnterprises with cloud commitments and security reviewsStrict data control, offline, high steady volume

Decision guide

  1. 1

    Start with hard constraints

    Data may not leave the EU? Must stay in your tenant? Offline? These eliminate options before quality comparisons begin.

  2. 2

    Follow your cloud

    Already on Azure with Microsoft procurement: Azure OpenAI is usually the smoothest path. On AWS: Bedrock gives you Claude and other models under your AWS account. On GCP: Vertex AI offers Gemini and Claude.

  3. 3

    Measure quality per task

    Run your eval set against two or three candidate models. Differences on your task and language often don’t match public benchmarks.

  4. 4

    Model the cost at real volume

    Include caching, routing and output length. See the LLM cost calculator.

  5. 5

    Keep an exit

    Abstract the provider behind your own gateway and keep prompts and evals in your repository.

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